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Rabbit Anti-PTPH1  antibody (bs-9187R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-9187R
英文名稱 Rabbit Anti-PTPH1  antibody
中文名稱 蛋白酪氨酸磷酸酶H1抗體
別    名 cytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase H1; protein tyrosine phosphatase non-receptor type 3; Protein-tyrosine phosphatase H1; PTN3_HUMAN; PTP H1; PTP-H1; PTPH1; PTPN3; Tyrosine-protein phosphatase non-receptor type 3.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  細(xì)胞骨架  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 104kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPH1/PTPN3: 11-110/913 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. PTP-H1 shares homology with the cytoskeletal-associated proteins band 4.1, ezrin, and talin and has been shown to contain a PDZ and band 4.1 domain. These domains are responsible for targeting proteins to the cytoskeleton-membrane interface, as well as mediating protein-protein interactions, recognizing C-terminal valine residues and binding to other PDZ domains. Overexpression of PTP-H1 may reverse transformation induced by oncogenic protein-tyrosine kinases, such as the members of the src family.

Function:
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Subcellular Location:
Cell membrane. Cytoplasm. cytoskeleton.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Contains 1 FERM domain.
Contains 1 PDZ (DHR) domain.
Contains 1 tyrosine-protein phosphatase domain.

SWISS:
P26045

Gene ID:
5774

Database links:

Entrez Gene: 5774 Human

Entrez Gene: 545622 Mouse

Omim: 176877 Human

SwissProt: P26045 Human

SwissProt: A2ALK8 Mouse

Unigene: 436429 Human

Unigene: 246552 Mouse



產(chǎn)品圖片
Sample: Lane 1: Human MCF-7 cell lysates Lane 2: Human HeLa cell lysates Lane 3: Human HepG2 cell lysates Primary: Anti-PTPH1 (bs-9187R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 104 kDa Observed band size: 120 kDa
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