| 產(chǎn)品編號(hào) | bs-8486R |
| 英文名稱 | Rabbit Anti-FNDC5 antibody |
| 中文名稱 | Ⅲ型纖維連接蛋白域蛋白2/5抗體 |
| 別 名 | Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; FNDC 5; FNDC5_HUMAN; FRCP2; Irisin. |
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Specific References (10) | bs-8486R has been referenced in 10 publications.
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| 研究領(lǐng)域 | 細(xì)胞生物 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Rabbit,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45646kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FNDC5: 81-143/212 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. Function: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway. Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. Post-translational modifications: The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. Similarity: Contains 1 fibronectin type-III domain. SWISS: Q8NAU1 Gene ID: 252995 Database links: Entrez Gene: 252995 Human Entrez Gene: 384061 Mouse Omim: 611906 Human SwissProt: Q8NAU1 Human SwissProt: Q8K4Z2 Mouse Unigene: 524234 Human Unigene: 44075 Mouse Unigene: 18757 Rat |
| 產(chǎn)品圖片 |
Sample:
HepG2(Human) Cell Lysate at 30 ug
NIH/3T3(Mouse) Cell Lysate at 30 ug
K562(Human) Lysate at 30 ug
Heart (Mouse) Lysate at 40 ug
Primary: Anti-FNDC5 ? (bs-8486R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 12/20 kD
Observed band size: 20 kD
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