| 產(chǎn)品編號(hào) | bs-7850R |
| 英文名稱 | Rabbit Anti-TTK antibody |
| 中文名稱 | 單極紡錘體蛋白激酶1抗體 |
| 別 名 | Dual specificity protein kinase TTK; ECSTY kinase; ESK; FLJ38280; hMPS1; Monopolar Spindle 1 Like 1; Mps 1; Mps-1; MPS1L1; Phosphotyrosine Picked Threonine Kinase; PYT; MPS1; TTK Protein Kinase; TTK_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 激酶和磷酸酶 細(xì)胞分化 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 95kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TTK: 601-700/857 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Mps1 (TTK) is a tyrosine and serine/threonine dual-specificity kinase required for centrosome duplication and the spindle checkpoint and has recently been shown to have a role in centrosome duplication. Alterations to Mps1 have been associated with cell transformation and chromosome instability in different tumor models. It is present in rapidly proliferating cell lines. Function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. Tissue Specificity: Present in rapidly proliferating cell lines. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. SWISS: P33981 Gene ID: 7272 Database links: UniProtKB/Swiss-Prot: P33981.2 |
