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Rabbit Anti-QSOX1  antibody (bs-6394R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-6394R
英文名稱 Rabbit Anti-QSOX1  antibody
中文名稱 巰基氧化酶1抗體
別    名 QSOX1_HUMAN; Sulfhydryl oxidase 1; QSCN6; EC:1.8.3.2; hQSOX; Quiescin Q6; UNQ2520/PRO6013; quiescin sulfhydryl oxidase 1; Q6;   
研究領域 腫瘤  細胞生物  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 80kDa
細胞定位 細胞漿 細胞膜 細胞外基質 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human QSOX1: 244-350/747 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.

Subunit:
Monomer.

Subcellular Location:
Isoform 1: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells.

Similarity:
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
Contains 1 ERV/ALR sulfhydryl oxidase domain.
Contains 1 thioredoxin domain.

SWISS:
O00391

Gene ID:
5768

Database links:

Entrez Gene: 5768 Human

Entrez Gene: 104009 Mouse

Entrez Gene: 84491 Rat

Omim: 603120 Human

SwissProt: O00391 Human

SwissProt: Q8BND5 Mouse

SwissProt: Q6IUU3 Rat

Unigene: 518374 Human

Unigene: 719176 Human

Unigene: 27035 Mouse

Unigene: 44920 Rat



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