| 產(chǎn)品編號(hào) | bs-6514R |
| 英文名稱(chēng) | Rabbit Anti-RLLM1 antibody |
| 中文名稱(chēng) | 胰腺癌轉(zhuǎn)移相關(guān)蛋白R(shí)LLM1抗體 |
| 別 名 | CGI 99; CGI99; CLE; Homeobox prox 1; RLLM1; Chromosome 14 open reading frame 166; CLE7; LCRP369; RLL motif containing 1; CN166_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 染色質(zhì)和核信號(hào) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 28kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RLLM1/C14orf166: 151-244/244 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. Function: The function of the C14orf266 gene has not yet been determined, but it is widely expressed, at high levels in heart and skeletal muscle and at intermediate levels in liver, pancreas, foetal brain and foetal lung. It is weakly expressed in adult brain, adult lung, placenta, foetal liver and foetal kidney, and overexpressed in many brain tumors.Cellular localization;Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. centrosome.May localize at the centrosome during mitosis. Subunit: Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex. Interacts with influenza A virus RNA polymerase subunits PA, PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19. Subcellular Location: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, centrosome. Note=May localize at the centrosome during mitosis. Tissue Specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors. Similarity: Belongs to the UPF0568 family. SWISS: Q9Y224 Gene ID: 51637 Database links: Entrez Gene: 51637 Human Entrez Gene: 68045 Mouse Omim: 610858 Human SwissProt: Q9Y224 Human SwissProt: Q9CQE8 Mouse Unigene: 534457 Human Unigene: 21932 Mouse |
