| 產(chǎn)品編號(hào) | bs-6104R |
| 英文名稱 | Rabbit Anti-SHPRH antibody |
| 中文名稱 | 組蛋白連接作用蛋白抗體 |
| 別 名 | E3 ubiquitin-protein ligase SHPRH; histone-linker; PHD and RING finger domain-containing helicase; SNF2; SNF2 histone linker PHD RING helicase; SHPRH_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞周期蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 193kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SHPRH: 401-500/1683 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Subunit: Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18. Tissue Specificity: Broadly expressed. Similarity: Belongs to the SNF2/RAD54 helicase family. Contains 1 H15 (linker histone H1/H5 globular) domain. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 PHD-type zinc finger. Contains 1 RING-type zinc finger. SWISS: Q149N8 Gene ID: 257218 Database links: Entrez Gene: 257218 Human Omim: 608048 Human SwissProt: Q149N8 Human Unigene: 723297 Human |
