| 產(chǎn)品編號(hào) | bs-2940R |
| 英文名稱 | Rabbit Anti-FUCA1 antibody |
| 中文名稱 | α-L巖藻糖苷酶抗體 |
| 別 名 | Alpha L fucosidase I; Alpha L fucoside fucohydrolase; Alpha-L-fucosidase 1; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; FUCA; FUCA1; FUCO_HUMAN; Tissue alpha L fucosidase; Tissue alpha-L-fucosidase. |
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Specific References (1) | bs-2940R has been referenced in 1 publications.
[IF=6.22] Gustafson, Callie M., et al. "Age-and sex-specific differences in blood-borne microvesicles from apparently healthy humans." Biology of Sex Differences 6.1 (2015): 1-10. Human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FUCA1/Alpha L fucosidase I: 321-420/466 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Alpha-L-fucosidase,AFU is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Subunit: Homotetramer. Subcellular Location: Lysosome. DISEASE: Fucosidosis (FUCA1D) [MIM:230000]: An autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the glycosyl hydrolase 29 family. SWISS: P04066 Gene ID: 2517 Database links: Entrez Gene: 2517 Human Entrez Gene: 71665 Mouse Omim: 612280 Human SwissProt: P04066 Human SwissProt: Q99LJ1 Mouse Unigene: 370858 Human Unigene: 439940 Mouse Unigene: 3469 Rat α-L-巖藻糖苷酶是一種催化含巖藻糖基的糖蛋白、糖脂等生物活性大分子水解酶的溶酶體酸性水解酶。其廣泛分布于人體組織細(xì)胞、血液和體液中。參與體內(nèi)糖蛋白、糖脂和寡糖的代謝。由于肝癌患者α-L-巖藻糖苷酶明顯升高，目前它被認(rèn)為是原發(fā)性肝癌的一種新的腫瘤標(biāo)記物。α-L巖藻糖苷酶升高：見于原發(fā)性肝癌、轉(zhuǎn)移性肝癌、肝硬化、急性肝炎等。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Liver tissue lysates
Lane 2: Mouse NIH/3T3 cell lysates
Primary: Anti-FUCA1 (bs-2940R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa
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