| 產(chǎn)品編號(hào) | bs-5945R |
| 英文名稱 | Rabbit Anti-SnoN antibody |
| 中文名稱 | Smad核轉(zhuǎn)錄共抑制因子抗體 |
| 別 名 | SKI like; Ski related oncogene; Ski related protein; SKIL; SnoA; SNO; SnoA; SnoI; SnoN; SKIL_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 77kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SnoN: 301-400/684 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SnoN may have a regulatory role in cell division or differentiation in response to extracellular signals. SnoN acts as a positive mediator of TGF beta induced transcription and cell cycle arrest in lung epithelial cells. The ability of SnoN to repress the growth inhibitory function of the Smad proteins is required for their transforming activity. Function: May have regulatory role in cell division or differentiation in response to extracellular signals. Subunit: Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Tissue Specificity: Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Similarity: Belongs to the SKI family. SWISS: P12757 Gene ID: 6498 Database links: Entrez Gene: 6498 Human Entrez Gene: 20482 Mouse Omim: 165340 Human SwissProt: P12757 Human SwissProt: Q60665 Mouse Unigene: 581632 Human Unigene: 15406 Mouse Smad核轉(zhuǎn)錄共抑制因子(SnoN)是一種拮抗劑，可嚴(yán)格調(diào)控轉(zhuǎn)化生長(zhǎng)因子-β1/smad(TGF-β1/Smad)信號(hào)的活性，從而保證在正常的生理?xiàng)l件下TGF-β1/smad信號(hào)輸出的穩(wěn)定性。 |
