| 產(chǎn)品編號(hào) | bs-2918R |
| 英文名稱 | Rabbit Anti-RAP1GAP antibody |
| 中文名稱 | RAP1GAP酶激活蛋白抗體 |
| 別 名 | Rap1 GTPase activating protein 1; RAP1 GTPase activating protein; RAP1GA1; Rap1ga1 protein; RAP1GAP1; RAP1GAPII; RAPGAP; KIAA0474; RPGP1_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Cow) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 73kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RAP1GAP.: 451-550/663 |
| 亞 型 | |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
RAP1GAP, an 85/95kDa protein, is a member of a family of GAPs specific for Rap1. Though to be an important tumor suppressor, Rap1GAP has no sequence homology with other GAPs such as RasGAP, RanGAP and RhoGAP. Purified as a cytosolic and membrane-bound protein, both isoforms consist of two monomers each contain a dimerization and a catalytic domain. Mutations in the GAP domain of the tumor suppressor tuberin, can cause benign tumor phenotype tuberous sclerosis. There are 2 isoforms produced by alternative splicing. Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. Subunit: Homodimer and heterodimer with RAP1B. Subcellular Location: Golgi apparatus membrane; Peripheral membrane protein. Tissue Specificity: Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. Similarity: Contains 1 GoLoco domain. Contains 1 Rap-GAP domain. SWISS: P47736 Gene ID: 5909 Database links: Entrez Gene: 5909 Human Entrez Gene: 110351 Mouse Omim: 600278 Human SwissProt: P47736 Human SwissProt: A2ALS5 Mouse Unigene: 148178 Human Unigene: 180763 Mouse Unigene: 18036 Rat RaplGAP在細(xì)胞的粘附連接及形成過程中所發(fā)揮著一定作用。RaplGAP是小分子G蛋白R(shí)apl的GTP酶激活蛋白(GTPase activating protein)，它可以加速rap1由活化形式(與GTP結(jié)合)轉(zhuǎn)變?yōu)槿セ罨问?與GDP結(jié)合)。由于粘附連接的破壞或延遲了粘附連接形成的過程，對(duì)腫瘤轉(zhuǎn)移有著密切的聯(lián)系。 |
