| 產(chǎn)品編號 | bs-4243R |
| 英文名稱 | Rabbit Anti-ITPR2 antibody |
| 中文名稱 | 5-三磷酸肌醇受體2抗體 |
| 別 名 | 4; 5-trisphosphate receptor; Inositol 1 4 5 trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 145 trisphosphate receptor type 2; InsP3 R2; InsP3R2; IP3 R2; IP3 receptor isoform 2; IP3R 2; IP3R2; ITPR 2; Itpr2; ITPR2_HUMAN; Type 2 inositol 1 4 5 trisphosphate receptor; Type 2 inositol 1; Type 2 inositol 145 trisphosphate receptor; Type 2 InsP3 receptor. |
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Specific References (1) | bs-4243R has been referenced in 1 publications.
[IF=7.129] Yixin Zhang. et al. Proteomic analysis of ITPR2 as a new therapeutic target for curcumin protection against AFB1-induced pyroptosis. ECOTOX ENVIRON SAFE. 2023 Jul;260:115073 IHC ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Cow) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 308kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ITPR2: 2351-2450/2701 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Function: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). Subunit: Homotetramer. Interacts with CABP1. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue Specificity: Isoform Short is found in skeletal muscle and heart. Post-translational modifications: Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. Similarity: Belongs to the InsP3 receptor family. Contains 5 MIR domains. SWISS: Q14571 Gene ID: 3709 Database links: Entrez Gene: 3709 Human Entrez Gene: 16439 Mouse Omim: 600144 Human SwissProt: Q14571 Human SwissProt: Q9Z329 Mouse Unigene: 512235 Human Unigene: 393003 Mouse Unigene: 7800 Mouse Unigene: 89152 Rat |
| 產(chǎn)品圖片 |
Tissue/cell: mouse heart tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-ITPR2 Polyclonal Antibody, Unconjugated(bs-4243R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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