| 產(chǎn)品編號 | bs-6190R |
| 英文名稱 | Rabbit Anti-Thyroxine Binding Globulin antibody |
| 中文名稱 | 甲狀腺素結(jié)合球蛋白抗體 |
| 別 名 | Serpin A7; Serpin A 7; SerpinA7; Serpin-A7; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7; SERPINA7; T4 binding globulin; TBG; THBG_HUMAN. |
| 研究領(lǐng)域 | 細胞生物 生長因子和激素 結(jié)合蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 44kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Thyroxine Binding Globulin: 231-330/415 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Thyroxine Binding Globulin (TBG) is one of three proteins responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3 triiodothyronine (T3) in the bloodstream, along with transthyretin and albumin. TBG has the highest affinity for T4 and T3, but is present in the lowest concentration of the three proteins. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 & T3, TBG is rarely more than 25% saturated with ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. Genomically, TBG is a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG is synthesized primarily in the liver. Function: Major thyroid hormone transport protein in serum. Subcellular Location: Secreted. Tissue Specificity: Expressed by the liver and secreted in plasma. DISEASE: Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. Similarity: Belongs to the serpin family. SWISS: P05543 Gene ID: 6906 Database links: Entrez Gene: 6906 Human Omim: 314200 Human SwissProt: P05543 Human Unigene: 76838 Human |
