| 產(chǎn)品編號 | bs-3694R |
| 英文名稱 | Rabbit Anti-CETP antibody |
| 中文名稱 | 膽固醇酯轉(zhuǎn)移蛋白抗體 |
| 別 名 | BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; Cholesteryl ester transfer protein precursor; HDLCQ10; Lipid transfer protein I. |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 脂蛋白 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 53kDa |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CETP: 355-450/493 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
High density lipoproteins (HDLs) have been proposed to function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease. Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Expressed by the liver and secreted in plasma. DISEASE: Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. SWISS: P11597 Gene ID: 1071 Database links: Entrez Gene: 1071 Human Omim: 118470 Human SwissProt: P11597 Human SwissProt: P22687 Rabbit Unigene: 89538 Human CETP系一疏水糖蛋白，膽固醇酯轉(zhuǎn)運蛋白--介導(dǎo)HDL中的膽固醇與VLDL中的甘油三酯等交換，促進HDL中的膽固醇凈轉(zhuǎn)運，可促進膽固醇酯在細(xì)胞與血漿脂蛋白間的轉(zhuǎn)運，參與膽固醇的逆轉(zhuǎn)運過程。 |
| 產(chǎn)品圖片 |
Sample:
Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti- CETP (bs-3694R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 53 kD
Observed band size: 53 kD
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