| 產(chǎn)品編號 | bs-2701R |
| 英文名稱 | Rabbit Anti-Sema6A antibody |
| 中文名稱 | Sema6A抗體 |
| 別 名 | semaphorin 6A; Sema Q; Sema VIA; SEMA6A-1; Semaphorin 6A-1; Semaphorin Q; Semaphorin VIA; HT018; SEM6A_HUMAN; SEMA; Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; SEMA6A 1; Sema6a; SEMA6A1; Semaphorin 6A 1; Semaphorin Q; Semaphorin VIA; Semaphorin-6A; Semaphorin-6A-1; SEMAQ; VIA. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 111kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Sema6A: 301-400/1030 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. However, the length of the cytoplasmic tail, which includes an EVL-binding site in SEMA6A and an Src-binding site in SEMA6B, suggests that these semaphorins may also function as receptors. SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. SEMA6A directly links the Ena/VASP and the semaphorin protein families since the SEMA6A protein is capable of selective binding to the protein EVL (Ena/VASP-like protein. Function: Can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Subunit: Active as a homodimer or oligomer. Interacts with EVL. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain. SWISS: Q9H2E6 Gene ID: 57556 Database links: Entrez Gene: 57556 Human Entrez Gene: 20358 Mouse Omim: 605885 Human SwissProt: Q9H2E6 Human SwissProt: O35464 Mouse Unigene: 156967 Human Unigene: 40909 Mouse |
