| 產(chǎn)品編號(hào) | bs-2524R |
| 英文名稱 | Rabbit Anti-CD151 antibody |
| 中文名稱 | CD151抗體 |
| 別 名 | CD151 antigen; CD151 molecule; GP27; Membrane glycoprotein SFA1; MER2; PETA3; Platelet endothelial tetraspan antigen 3; RAPH; SFA 1; SFA1; Tetraspanin24; TSPAN24; CD151_HUMAN; Platelet-endothelial tetraspan antigen 3; PETA-3; Tetraspanin-24; Tspan-24; CD151. |
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Specific References (1) | bs-2524R has been referenced in 1 publications.
[IF=5.793] Ceshu Gao. et al. Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke. J Neuroinflamm. 2021 Dec;18(1):1-16 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 細(xì)胞膜受體 細(xì)胞粘附分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 28kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD151: 101-200/253 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]. Function: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Subunit: Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes. DISEASE: Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the tetraspanin (TM4SF) family. SWISS: P48509 Gene ID: 977 Database links: Entrez Gene: 977 Human Omim: 602243 Human SwissProt: P48509 Human Unigene: 654379 Human CD151蛋白是四跨膜超家族蛋白(transmembrane-4 superfamily，TM4SF)成員，參與調(diào)節(jié)細(xì)胞的形態(tài)和極性、促進(jìn)細(xì)胞黏附和遷移，并在體外血管形成中發(fā)揮著重要作用，該蛋白與血管新生有關(guān)。 |
| 產(chǎn)品圖片 |
Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-CD151 (bs-2524R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 28 kD
Observed band size: 28 kD
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