| 產(chǎn)品編號(hào) | bs-2493R |
| 英文名稱(chēng) | Rabbit Anti-TNFRSF12A/CD266 antibody |
| 中文名稱(chēng) | 腫瘤壞死因子配體超家族成員12A（CD266）抗體 |
| 別 名 | CD 266; CD266; CD266 antigen; TWEAKR; FGF inducible 14; FGF-inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN 14; FN14; TNFRSF 12A; TNR12_HUMAN; Tumor necrosis factor receptor superfamily member 12A; TWEAK R; Tweak receptor; Tweak-receptor; TweakR; Type I transmembrane protein Fn 14; Type I transmembrane protein Fn14. |
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Specific References (1) | bs-2493R has been referenced in 1 publications.
[IF=4.26] Connolly et al. Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma. (2018) Sci.Rep. 8:1180 IF(IHC-P) ; Mouse, Rat.
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| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 細(xì)胞膜受體 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 11kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNFRSF12A: 61-129/129 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
TWEAK (otherwise known as TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A), is a member of the TNF family and was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins.
Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. Function: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Subunit: Associates with TRAF1 and TRAF2, and probably also with TRAF3. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. Similarity: Contains 1 TNFR-Cys repeat. SWISS: Q9NP84 Gene ID: 51330 Database links: Entrez Gene: 51330 Human Entrez Gene: 27279 Mouse Omim: 605914 Human SwissProt: Q9NP84 Human SwissProt: Q9CR75 Mouse Unigene: 355899 Human Unigene: 28518 Mouse Unigene: 105040 Rat |
