| 產(chǎn)品編號(hào) | bs-1845R |
| 英文名稱 | Rabbit Anti-LRIG2 antibody |
| 中文名稱 | LRIG2抗體 |
| 別 名 | DKFZp451C181; KIAA0806; LIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 precursor; LRIG2_HUMAN; UFS2; LIG-2. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Dog,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 117kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRIG2: 701-800/1065 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
LRIG2 is produced in all human glioma cell lines and localizes to perinuclear compartments, cytoplasmic compartments and the cell surface. It acts as a negative feedback regulator of signaling through enhanced receptor ubiquitination and accelerated intracellular degradation. LRIG2 may function as a tumour suppressor since it downregulates the expression of EGF and the related proteins ErbB-2, ErbB-3 and ErbB-4, which all inhibit cancer cells from growth, migration and invasion. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Tissue Specificity: Detected in all tissues analyzed. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: O94898 Gene ID: 9860 Database links: Entrez Gene: 9860 Human Omim: 608869 Human SwissProt: O94898 Human Unigene: 448972 Human LRIG1屬于LRIGs基因家族。LRIGs是新發(fā)現(xiàn)的一類基因，在哺乳動(dòng)物體內(nèi)廣泛存在，目前發(fā)現(xiàn)該家族至少包括三個(gè)成員：LRIG1、LRIG2和LRIG3，是一類結(jié)構(gòu)相似的跨膜糖蛋白，該蛋白人、鼠的同源性較高。 目前在腫瘤方面的研究較多，有研究認(rèn)為：LRIG1是通過下調(diào)EGFR的表達(dá)來抑制其下游重要信號(hào)傳導(dǎo)通路的激活而發(fā)揮抑癌作用，LRIG1在抑制腫瘤轉(zhuǎn)移中具有重要作用。 |
| 產(chǎn)品圖片 |
Sample:
Lymph node (Mouse) Lysate at 40 ug
Primary: Anti- LRIG2 (bs-1845R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 117 kD
Observed band size: 117 kD
Sample:
Lane 1: Human HeLa cell lysates
Lane 2: Human HepG2 cell lysates
Primary: Anti-LRIG2 (bs-1845R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 117 kDa
Observed band size: 117 kDa
Sample:
Thymus (Mouse) Lysate at 40 ug
Primary: Anti- LRIG2 (bs-1845R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 117 kD
Observed band size: 117 kD
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