| 產(chǎn)品編號 | bs-1574R |
| 英文名稱 | Rabbit Anti-RRM1 antibody |
| 中文名稱 | 核糖核苷酸還原酶1抗體 |
| 別 名 | ribonucleotide reductase R1 mRNA; R1; Ribonucleoside diphosphate reductase large subunit ; Ribonucleoside diphosphate reductase M1 chain; Ribonucleoside diphosphate reductase subunit M1; Ribonucleotide reductase large chain; Ribonucleotide reductase large subunit; Ribonucleotide reductase M1 polypeptide; Ribonucleotide reductase R1 subunit; RIR 1; RIR1; RR 1; RR1; RRM 1; RIR1_HUMAN. |
| 研究領(lǐng)域 | 細胞生物 染色質(zhì)和核信號 激酶和磷酸酶 細胞分化 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 90kDa |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RRM1: 733-778/792 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer to treatment. Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Subunit: Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Subcellular Location: Cytoplasm. Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family. Contains 1 ATP-cone domain. SWISS: P23921 Gene ID: 6240 Database links: Entrez Gene: 6240 Human Entrez Gene: 20133 Mouse Omim: 180410 Human SwissProt: P23921 Human SwissProt: P07742 Mouse Unigene: 445705 Human Unigene: 197486 Mouse Unigene: 162454 Rat 核糖核苷酸還原酶普遍存在于很多生物中,是生物體內(nèi)唯一的催化4種核糖核苷酸還原并生成相應的脫氧核糖核苷酸的酶. 核糖核苷酸還原酶1也是DNA合成和修復的關(guān)鍵酶和限速酶,對細胞的增殖和分化起著調(diào)控作用。 |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關(guān)于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
