| 產(chǎn)品編號 | bs-0928R |
| 英文名稱 | Rabbit Anti-phospho-heterochromatin protein 1 (pTyr24) antibody |
| 中文名稱 | 磷酸化異染色質(zhì)蛋白1抗體（果蠅） |
| 別 名 | heterochromatin protein 1 (phospho Tyr24); heterochromatin protein 1 (phospho Y24); Antigen p25; Cbx 5; Cbx5; Chromobox homolog 5 (Drosophila HP1 alpha); Chromobox homolog 5 (HP1 alpha homolog Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Chromobox protein homologue 5; Heterochromatin protein 1 alpha; Heterochromatin protein 1; Heterochromatin protein 1 homolog alpha; HP 1; HP 1A; HP1 alpha homolog; HP1A; HP1Hs alpha; HP1Hs-alpha. |
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Specific References (1) | bs-0928R has been referenced in 1 publications.
[IF=3.057] Terzuoli et al. Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation. (2014) PLoS.On. 9:e84358 WB ; Human.
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| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 免疫學(xué) 染色質(zhì)和核信號 昆蟲 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Fruit Fly) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23kDa |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from Fruit Fly HP1 around the phosphorylation site of Tyr24: EE(p-Y)AV |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane.
HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required
for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin. SWISS: P05205 Gene ID: N/A Database links: GenBank: ACI96782.1 異染色質(zhì)蛋白1（Heterochromatin protein 1 (HP1)）一般認(rèn)為是異染色質(zhì)的維持者，異染色質(zhì)是轉(zhuǎn)錄沉默的固縮DNA，常常與中心粒等區(qū)域有關(guān)。這種固縮的DNA被認(rèn)為是轉(zhuǎn)錄因子無法接近的，但近期的Science上發(fā)表的兩篇報(bào)道對這個(gè)觀點(diǎn)提出了挑戰(zhàn)。 這個(gè)新的研究提出HP1可能是異染色質(zhì)活性調(diào)控的重要因子，在細(xì)胞生理活動中具有的重要功能。 |
