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Rabbit Anti-Tyrosine Hydroxylase  antibody (bs-0016R)  
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產(chǎn)品編號 bs-0016R
英文名稱 Rabbit Anti-Tyrosine Hydroxylase  antibody
中文名稱 酪氨酸羥化酶抗體
別    名 DYT14; DYT5b; ple; Protein Pale; c; The; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyk2; TY3H_HUMAN; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH.  
Specific References  (10)     |     bs-0016R has been referenced in 10 publications.
[IF=14.612] Na Zhou. et al. Specific Fluorescent Probe Based on “Protect–Deprotect” To Visualize the Norepinephrine Signaling Pathway and Drug Intervention Tracers. J Am Chem Soc. 2020;142(41):17751–17755  IF ;  Human.  
[IF=6.35] Yue Y et al. Noradrenaline-Specific,?Efficient?Visualization?in?Brain?Tissue?Triggered?by?Unique?Cascade Nucleophilic?Substitution. Anal Chem.?2019 Feb 5;91(3):2255-2259.  IHF ;  Mouse.  
[IF=5.811] Lang Xiu-Yuan. et al. Coeloglossum viride Var. Bracteatum Extract Attenuates MPTP-Induced Neurotoxicity in vivo by Restoring BDNF-TrkB and FGF2-Akt Signaling Axis and Inhibiting RIP1-Driven Inflammation. FRONT PHARMACOL. 2022 Apr;0:1571  WB ;  Mouse.  
[IF=4.526] Wen Yi. et al. Suppression of axonal attractant netrin-1 injured dopaminergic neuronal and motor function of mice during manganese over-exposure. METALLOMICS. Metallomics. 2022 Apr;:  WB ;  Mouse.  
[IF=2.784] Luo BB et al. Connexin 43 reduces susceptibility to sympathetic atrial fibrillation. INTERNATIONAL JOURNAL OF MOlecular medici. 2018,42(2):1125-1133.  IHC-P ;  Dog.  
[IF=2.761] Ozbey G et al. Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation. Pharmacol Rep. 2020 Mar 23.  IHC ;  mouse.  
[IF=2.655] Xiaokereti, Jiasuoer. et al. Renal denervation alleviates chronic obstructive sleep apnea-induced atrial fibrillation via inhibition of atrial fibrosis and sympathetic hyperactivity. SLEEP BREATH. 2023 Feb;:1-14  IHC,IF ;  Dog.  
[IF=1.966] Tian L et al. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 2019 Nov 25.  IHC-P ;  rat&mink.  
[IF=1.19] Shu et al. Connexin 43 is involved in the sympathetic atrial fibrillation in canine and canine atrial myocytes. (2017) Anatol.J.Cardiol. 18:3-9  IHC ;  Canine.  
[IF=1.09] Yu, Yaping, et al. "Overexpression of lactate dehydrogenase-A in human intrahepatic cholangiocarcinoma: its implication for treatment." World Journal of Surgical Oncology 12.1 (2014): 78.  WB ;  Human.  
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 60kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TH: 101-165/528 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Function:
Plays an important role in the physiology of adrenergic neurons.

Tissue Specificity:
Mainly expressed in the brain and adrenal glands.

DISEASE:
Defects in TH are the cause of Segawa syndrome autosomal recessive (ARSEGS) [MIM:605407]. A form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.

Similarity:
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

SWISS:
P07101

Gene ID:
7054

Database links:

Entrez Gene: 7054 Human

Entrez Gene: 21823 Mouse

Entrez Gene: 25085 Rat

Omim: 191290 Human

SwissProt: P07101 Human

SwissProt: P24529 Mouse

SwissProt: P04177 Rat

Unigene: 435609 Human

Unigene: 1292 Mouse

Unigene: 11082 Rat



神經(jīng)細(xì)胞標(biāo)志物
酪氨酸羥化酶(TH)是兒茶酚胺類神經(jīng)遞質(zhì)即多巴胺、去甲腎上腺素、腎上腺素生物合成過程所需的限速酶,它以四氫生物喋呤啶(BH4)為輔酶,催化酪氨酸的羥化而生成多巴(DOPA)。
已知在患帕金森病(Parkinson disease,PD)時,腦內(nèi)多巴胺(dopamine,DA)的減少與此酶活性低下有關(guān)。因此對PD模型動物來說,若將TH基因植入腦內(nèi),便可以提高腦內(nèi)DA水平而達(dá)到基因治療目的。
產(chǎn)品圖片
Sample: adipocyte (mouse) Lysate at 5-10 ug model A, model B, model C are from different mice; Primary: Anti-Tyrosine Hydroxylase(bs-0016R) at 1/2000 dilution Predicted band size: 60 kD Observed band size: 60 kD
Sample: PC-3 (Mouse) Lysate at 30 ug Primary: Anti-Tyrosine Hydroxylase (bs-0016R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1:5000 dilution; Predicted band size:60 kD Observed band size:60 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tyrosine Hydroxylase) Polyclonal Antibody, Unconjugated (bs-0016R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tyrosine Hydroxylase) Polyclonal Antibody, Unconjugated (bs-0016R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Tyrosine Hydroxylase Polyclonal Antibody, Unconjugated(bs-0016R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tyrosine Hydroxylase) Polyclonal Antibody, Unconjugated (bs-0016R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (bs-0295G-FITC) for 90 minutes, and DAPI for nuclei staining.
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Tyrosine Hydroxylase) Polyclonal Antibody, Unconjugated (bs-0016R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (bs-0295G-FITC) for 90 minutes, and DAPI for nuclei staining.
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