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Rabbit Anti-SP7/Osterix  antibody (bs-1110R)  
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產(chǎn)品編號(hào) bs-1110R
英文名稱 Rabbit Anti-SP7/Osterix  antibody
中文名稱 成骨相關(guān)轉(zhuǎn)錄因子抗體
別    名 SP7_HUMAN; Transcription factor Sp7; OSX; Zinc finger protein osterix; Sp7 transcription factor; Osterix;  
Specific References  (30)     |     bs-1110R has been referenced in 30 publications.
[IF=8.724] Yong Tang. et al. Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering. Bioact Mater. 2021 Jul;6:2039  IF,IHC ;  Mouse.  
[IF=7.571] Rui Zhang. et al. Multifunctional silicon calcium phosphate composite scaffolds promote stem cell recruitment and bone regeneration. J MATER CHEM B. 2022 Jun;:  IHC ;  Rat.  
[IF=7.419] Jingyuan Wen. et al. Qiangguyin inhibited fat accumulation in OVX mice through the p38 MAPK signaling pathway to achieve anti-osteoporosis effects. BIOMED PHARMACOTHER. 2023 Feb;158:114122  IHC ;  Mouse.  
[IF=7.242] Yong Tang. et al. Laminin alpha 4 promotes bone regeneration by facilitating cell adhesion and vascularization. Acta Biomater. 2021 Mar;:  IF,IHC ;  Mouse.  
[IF=6.576] Kohei Arakawa. et al. The difference in joint instability affects the onset of cartilage degeneration or subchondral bone changes. Osteoarthr Cartilage. 2021 Dec;:  IHC ;  Mouse.  
[IF=6.52] Agarwal, Shailesh, et al. "Analysis of bone‐cartilage‐stromal progenitor populations in trauma induced and genetic models of heterotopic ossification." STEM CELLS (2016).  IHC-P ;  Mouse.  
[IF=6.39] Xiaoxia Hao. et al. Bone deterioration in response to chronic high-altitude hypoxia is attenuated by a pulsed electromagnetic field via the primary cilium/HIF-1α axis. J BONE MINER RES. 2023 Jan;:  WB ;  Rat.  
[IF=6.28] Chen et al. Diet derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. (2013) J.Bone.Miner.Res.  WB ;  Mouse.  
[IF=6.064] Song Xiaoliang. et al. Bioinspired Protein/Peptide Loaded 3D Printed PLGA Scaffold Promotes Bone Regeneration. FRONT BIOENG BIOTECH. 2022 Jul;0:1195  WB ;  Rabbit.  
[IF=5.638] Cui Q et al. Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway. Cell Death Dis. 2019 Feb 20;10(3):172.  WB ;  Mouse.  
[IF=5.587] Agarwal et al. Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification. (2016) Stem.Cells. 34:1692-701  IF ;  Human,Mouse.  
[IF=5.3] Rajshankar, Dhaarmini, Yongqiang Wang, and Christopher A. McCulloch. "Osteogenesis requires FAK-dependent collagen synthesis by fibroblasts and osteoblasts." The FASEB Journal (2016): fj-201600645R.  WB ;  Mouse.  
[IF=5.23] Li, Shao, et al. "A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development." Scientific Reports 7 (2017): 40505.  WB ;  Mouse.  
[IF=5.23] Agarwal, Shailesh, et al. "Local and Circulating Endothelial Cells Undergo Endothelial to Mesenchymal Transition (EndMT) in Response to Musculoskeletal Injury." Scientific Reports 6 (2016): 32514.  WB ;  Mouse.  
[IF=4.165] Yu-Ting Yen. et al. PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Commun Biol. 2021 Jun;4(1):1-12  WB,IHC ;  Mouse.  
[IF=4.122] ?brahim Halilullah Erbay. et al. Bioengineering bone-on-a-chip model harnessing osteoblastic and osteoclastic resolution. ADV ENG MATER. 2022 Dec;:  IF ;  Mouse.  
[IF=3.68] Dong, Weijie, et al. "Phenotypic characterization of craniofacial bone marrow stromal cells: unique properties of enhanced osteogenesis, cell recruitment, autophagy, and apoptosis resistance." Cell and Tissue Research (2014): 1-11.  WB ;  Rat.  
[IF=3.662] Jiarui Lu. et al. Injectable Col-Ⅰ/CS hydrogel enhances bone regeneration in mice tibial mono-cortical defect with impaired osteogenesis. MATER TODAY COMMUN. 2022 Aug;32:104070  IF ;  Mouse.  
[IF=3.448] Chang Z et al. Reticulocalbin 2 enhances osteogenic differentiation of human vascular smooth muscle cells in diabetic conditions. Life Sci. 2019 Sep 15;233:116746.  WB ;  Human.  
[IF=3.42] Tang, Zhurong, et al. "Comparison of ectopic bone formation process induced by four calcium phosphate ceramics in mice." Materials Science and Engineering: C (2016).  IHC-P ;  Mouse.  
[IF=3.347] Yongkui Wang. et al. Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling. Toxicol Appl Pharm. 2020 Dec;409:115333  WB,IHC ;  Rat, Mouse.  
[IF=2.86] Kishi, Yuta, et al. "PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP-2 Signaling Pathway."International Journal of Molecular Sciences 16.10 (2015): 24820-24838.  WB ;  Mouse.  
[IF=2.626] Zhao, Gang. et al. LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression. 2021 Nov 15  WB,IHC ;  Mouse,Human.  
[IF=2.33] Qian, Dong-Yang, et al. "Differential circRNA expression profiles during the BMP2-induced osteogenic differentiation of MC3T3-E1 cells." Biomedicine & Pharmacotherapy 90 (2017): 492-499.  WB ;  Mouse.  
[IF=2.2] Ranganathan, Kavitha, et al. "The role of the adaptive immune system in burn-induced heterotopic ossification and mesenchymal cell osteogenic differentiation." Journal of Surgical Research 206.1 (2016): 53-61.  IF(IHC-P) ;  Mouse.  
[IF=2.1] Bo Zhang. et al. Neuropeptide?Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3?E1 cells via an autocrine mechanism. Mol Med Rep. 2020 Nov;22(5):4376-4382  WB ;  Mouse.  
[IF=1.56] Wang, Yilin, et al. "Synergistic effects of overexpression of BMP?2 and TGF?β3 on osteogenic differentiation of bone marrow mesenchymal stem cells." Molecular Medicine Reports (2016): 11.  WB ;  Rabbit.  
[IF=0.57] Shi, Hua-Li, et al. "Effect of polygonimitin C on bone formation and resorption in human osteoblast-like MG63 cells." Tropical Journal of Pharmaceutical Research 16.7 (2017): 1595-1600.  WB ;  Human.  
[IF=0] Bihari C et al. Suboptimal Level of Bone-Forming Cells in Advanced Cirrhosis are Associated with Hepatic Osteodystrophy. (2018) Hepatol Commun.Sep 4;2(9):1095-1110.  IHC ;  Human.  
[IF=0] Schlie-Wolter, S., et al. Osteogenic Differentiation of Human Adipose-Derived Stem Cells (hASC): Role of FAK and Ras-MAPK Signaling. (2016) J Stem Cell Regen Bio 2(2): 1- 19  WB ;  Human.  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse
產(chǎn)品應(yīng)用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 45kDa
檢測(cè)分子量 45-50/56
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SP7: 271-380/431 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]

Function:
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).

Subunit:
Interacts with NO66; the interaction is direct and inhibits transcription activator activity.

Subcellular Location:
Nucleus.

Tissue Specificity:
Osteoblast/chondrocyte specific.

DISEASE:
Osteogenesis imperfecta 12 (OI12) [MIM:613849]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

SWISS:
Q8TDD2

Gene ID:
121340

Database links:

Entrez Gene: 121340 Human

Entrez Gene: 170574 Mouse

Entrez Gene: 300260 Rat

Omim: 606633 Human

SwissProt: Q8TDD2 Human

SwissProt: Q5RM08 Mouse

SwissProt: Q8VI67 Mouse

SwissProt: Q6IMK1 Rat



Osterix成骨相關(guān)轉(zhuǎn)錄因子是一種具有鋅指基序結(jié)構(gòu)域的轉(zhuǎn)錄因子，在體內(nèi)的表達(dá)對(duì)成骨細(xì)胞具有特異性。該蛋白只在發(fā)育的骨組織中特異性表達(dá)，是成骨細(xì)胞分化和骨形成過(guò)程中所必需的轉(zhuǎn)錄因子。骨髓基質(zhì)干細(xì)胞分化為表達(dá)典型的成骨性標(biāo)志基因的成骨細(xì)胞需要OSX的調(diào)控。
產(chǎn)品圖片
Sample:Spinal cord (Mouse) Lysate at 40 ug Primary: Anti-Osterix(bs-1110R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45kD Observed band size: 50kD
Sample: Lane 1: Mouse Embryo tissue lysates Lane 2: Mouse Testis tissue lysates Lane 3: Mouse Cerebrum tissue lysates Primary: Anti-SP7/Osterix (bs-1110R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45 kDa Observed band size: 47 kDa
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