| 產(chǎn)品編號(hào) | bs-0053R |
| 英文名稱 | Rabbit Anti-Caspase-13 + 4 antibody |
| 中文名稱 | 半胱胺酸蛋白酶蛋白-13抗體 |
| 別 名 | CASP-13; CASP4; Caspase 13 subunit 1; Caspase 13 subunit 2; Caspase 4; Caspase 4 subunit 1; Caspase 4, apoptosis related cysteine; CASPD_BOVIN; Caspase-13; Evolutionary related interleukin-1-beta-converting enzyme; ERICE. |
| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 43kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from bovine Caspase-13: 71-130/377 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Caspase-13 (also designated Evolutionarily related interleukin-1beta converting enzyme ; ERICE) involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. [subunit] Heterodimer of a small and a large subunit. The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8. Mainly expressed in peripheral blood lymphocytes, spleen and placenta. Belongs to peptidase family C14. Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. Tissue Specificity: Mainly expressed in peripheral blood lymphocytes, spleen and placenta. Similarity: Belongs to the peptidase C14A family. Contains 1 CARD domain. SWISS: O75601 Gene ID: 338039 Database links: SwissProt: O75601 Bovine
SwissProt: Q5E9C1 Bovine
Entrez Gene: 338039 Bovine Caspase-13 (也稱 Evolutionarily related interleukin-1beta convertingenzyme; ERICE) 參與活化Caspase級(jí)聯(lián)反應(yīng)，實(shí)施調(diào)亡。 它既能激活某些蛋白質(zhì),細(xì)胞死亡所必需的蛋白質(zhì)；又能使某些蛋白質(zhì)失活以使細(xì)胞能夠存活。它的異原二聚體構(gòu)成大、小兩種亞單位，這兩種亞單位來源于前體序列由一個(gè)自動(dòng)催化機(jī)制而形成或由Caspase-8剪切而成。 Caspase-13主要表達(dá)于外周淋巴細(xì)胞、脾臟和胎盤。屬于肽酶家族C14成員. |
