| 產(chǎn)品編號 | bs-0299R |
| 英文名稱 | Rabbit Anti-Adenylate Kinase 1 antibody |
| 中文名稱 | 腺苷酸激酶-1抗體 |
| 別 名 | AK 1; AK1; AK-1; KAD1_HUMAN; Adenylate kinase isoenzyme 1; Adenylate kinase soluble; ATP AMP transphosphorylase; Myokinase; ATP-AMP transphosphorylase 1. |
| 研究領(lǐng)域 | 腫瘤 心血管 信號轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse,Goat,Monkey) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 21kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Adenylate Kinase 1: 131-194/194 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Subunit: Monomer. Subcellular Location: Cytoplasm. DISEASE: Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631]. Similarity: Belongs to the adenylate kinase family. SWISS: P00568 Gene ID: 203 Database links: Entrez Gene: 203 Human Entrez Gene: 11636 Mouse Omim: 103000 Human SwissProt: P00568 Human SwissProt: Q9R0Y5 Mouse Unigene: 175473 Human Unigene: 29189 Mouse Unigene: 79537 Rat AK1存在于人類紅細(xì)胞上及某些組織中的具有遺傳多態(tài)性的同工酶, 腺苷酸激酶催化 ATP，AMP 和 ADP 的轉(zhuǎn)化，它是維持各種腺苷酸平衡的關(guān)鍵酶。因此，腺苷酸激酶就成為調(diào)控腺苷酸庫大小的靶標(biāo)分子。 |
